Preclinical safety testing of an affinity-optimised MAGE-A10 T cell receptor for adoptive T cell therapy
نویسندگان
چکیده
Background Preclinical safety testing for adoptive immunotherapies utilising T cell receptor-(TCR) engineered T cells relies on stringent target validation and a robust pre-clinical specificity testing strategy. Specific safety concerns include ontarget off-tumour toxicity and off-target toxicity. Avoidance of these toxicities requires that the expression profile of the target antigen be shown to be specific to tumour tissues, and that the TCR is shown to be specific.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015